A road movie for romantics, Patagonia follows the journeys of two women – one looking for her past, the other for her future. The film intercuts between their stories, in which one of them travels south to north through the Welsh springtime and the other east to west through the Argentine autumn. It is a film of intimate moments that play out against sweeping panoramic landscapes, complemented by a hauntingly beautiful soundtrack. It stars singer Duffy in her acting debut.
When Rhys (Matthew Gravelle) is required to travel to South America to do a work assignment on Patagonia's Welsh community, his partner, Gwen (Nia Roberts), goes with him, despite the fact they are having relationship difficulties. While there, however, Gwen falls for their driver, Mateo (Matthew Rhys). At the same time, an elderly woman, Cerys, leaves Patagonia and heads to Wales where she hopes to discover her family's history. She is accompanied by her nephew, Alejandro, who becomes romantically involved with local girl Sissy (Duffy).